LETM2 and cancer: Moreover, transcriptomic data from The Cancer Genome Atlas (TCGA) showed that NSD3-amplified LUSC patients featured a panel of differentially expressed genes (DEGs), such as LETM2, STAR, KRT13, ADAM32, and EIF4EBP1, which have considerable impacts on cell growth, metastasis, and anti-tumor immunity in various cancers (Figure 1D, Supplementary Table S1).