Interestingly, ssGSEA (GSVA) showed that the hyperactivity of NSD3 further accelerated the immune-desert phenotype in the tumor, as indicated by the reduced infiltration of several immune cell types (e.g., activated DCs, B cells, and mast cells) and repressed activities of the type II-IFN response (Figure 6H, Supplementary Figure S4D,E). This evidence concerns the gene NSD3 and neoplasm.