TP53 and acute myeloid leukemia: In a study conducted on 500 AML patients, Hou et al. found TP53 mutation to be associated with an inferior response rate (complete remission [CR] rate 28.6% vs. 80.2%, p < 0.0001) and shorter overall survival (OS) (median, 5 vs. 35 months, p < 0.001) compared to unmutated patients [29].