Stat3 can be activated by various molecules that are over-produced in CRC tissue, such as interleukin (IL)-6, IL-21, IL-22, growth factors (e.g., EGFR, PDGFR), and non-receptor tyrosine kinases (e.g., Src) [9,10,11,12,13]. This evidence concerns the gene EGFR and colorectal carcinoma.