Interestingly, Smad7 knockdown also attenuated the p-Stat3 expression induced by IL-22 (Figure 3B and Figure S5), a cytokine that is over-produced in CRC tissue [20] and is able to signal in CRC cells by using a heterodimeric receptor composed of IL-22R and IL-10R2 in humans (IL-10Rβ in mice) [21,22]. Here, IL22 is linked to colorectal carcinoma.