Mutations in the mitochondrial tumor suppressor gene pathway involve the succinate dehydrogenase subunits SDHA (most frequently), SDHD, SDHC (c.24delC in the exon 1 of SDHC and resulting in the frameshift variant p.His8GlnfsTer39, with a mutant allele burden >90%) and SDHB (c.287-1G > C in intron 3 with a mutant allele burden >95%) [30,31]. Here, SDHC is linked to neoplasm.