Some GISTs are connected with FGFR (fibroblast growth factor receptor) genetic abnormalities, including oncogenic fusion FGFR1::HOOK3, FGFR1::TACC1, activating FGFR1 missense mutations p.K656E and p.N546K, FGF4 overexpression; FGF2 overexpression or gain in FGFR2 in imatinib-resistant GIST cells [13,22,23,24,25]. Here, FGFR1 is linked to gastrointestinal stromal tumor.