An in vitro study showed that IL-6 and IL-8 in senescence-conditioned medium (SCM) from senescent foreskin fibroblasts, HCA2, can increase the expression of vimentin, ZEB-1, SNAIL-1, and SNAIL-2/Slug in MCF-7 breast cancer cells. This evidence concerns the gene CXCL8 and breast carcinoma.