Ultimately, with this type of assemblage, various components of the immune system, such as complement factors, lymphocytes (TILs), and their subsets (including CD8+ cytotoxic T cells, CD4+ helper T cells, CD163+ and CD68+ macrophages and MDSCs, CD57+ NK cells, and FOXP3+ T regulatory cells (Tregs) [40,41,42,43]) often fail to eliminate the tumor, but rather contribute to the stabilization of tumor progression and help to evade immune recognition [36,44]. This evidence concerns the gene CD8A and neoplasm.