Typical CRC copy-number variations with recurrent gains on 7p, 12q, and 20p/q occurred (encoding, for example, for BCL2L1 and SRC) and losses within 1p, 4q, 8p, 14q, 15q, 17p, and 18p/q (resulting in deletions of, for example, ARID1A, TP53, and SMAD4) (Figure S3, Table S3). Here, SMAD4 is linked to colorectal carcinoma.