From a biological perspective, POLE-mutated tumors displayed higher CD8+ T cell infiltration, expression of cytotoxic markers, and immune checkpoints compared with POLE wild-type pMMR/MSS tumors [53], while they showed a similar enrichment of CD8+ as in dMMR/MSI-H tumors, revealing a similar biology between these two subgroups of CRC tumors. The gene discussed is POLE; the disease is colorectal carcinoma.