However, several studies have indicated that YAP1 expression is associated with increased immune cell infiltration in various solid tumors including pancreatic cancer [35], ovarian cancer [36], and hepatocellular carcinoma [37], etc. So far, direct correlation of matrix stiffness-YAP1- immunosuppression has not been well studied. The gene discussed is YAP1; the disease is familial pancreatic carcinoma.