Although some staining was present in the media of non-aneurysmal mouse aortae (Figure 1A, PBS infusion), transmural IFNAR1 stain was dramatically increased in experimental AAAs (Figure 1B, PPE infusion), with a significantly larger IFNAR1 stain-positive area in aneurysmal (0.8 ± 0.2: positive staining/total ACS area) vs. non-aneurysmal (0.3 ± 0.1) aortae (p < 0.05, 3 mice/group). The gene discussed is IFNAR1; the disease is achalasia-alacrima syndrome.