However, TNP was later found to be more potent against IP6K, with an IC50 of 0.47 μM [33] compared to an IC50 of 10 μM against IP3K [34], and demonstrated anti-obesity and anti-diabetic effects in a mouse model of high fat diet-induced obesity [28,35]. Here, ITPKB is linked to obesity due to melanocortin 4 receptor deficiency.