ABCB1 and ovarian adenocarcinoma: Therefore, Drinberg et al. [67] evaluated if sertraline could effectively be used as a multiple drug resistance modulator in vitro in the human ovarian adenocarcinoma cell lines OVCAR-8 and NCI/ADR-Res (NAR), a sub-line of OVCAR-8 expressing P-glycoprotein, and in vivo using human ovarian adenocarcinoma NCI-ADR/RES (NAR) xenografts.