Notably, these consistently observed changes in gene expression between wild-type and Pten null prostates included orthologs of many genes functionally associated with human prostate cancer, such as NKX3.1 [63], TNF [64], CD44 [65], KLF5 [66], ASNS [67], CXCL16 [68], IL1RN [69], LY6A/SCA1 [70], GATA3 [71], TNS1 [72] and STAT1 [73], and encoding a number of reported relevant biomarkers including ANXA2 [74], KRT19 [75], SDC1 [76], RHOU [77], SEPT9 [78], ANPEP [79], TSPAN8 [80], COL4A6 [81] and ATF6 [82] (Supplementary Table S5). This evidence concerns the gene CD44 and Familial prostate cancer.