Differential hydroxymethylation is observed most commonly in genes associated with pancreas development or function, including GATA-binding protein 4 (GATA4), GATA-binding protein 6 (GATA6), prospero homeobox protein 1 (PROX1), one cut homeobox 1 (ONECUT1), and Meis homeobox 2 (MEIS2), and in genes related to cancer pathogenesis, such as Yes1 associated transcriptional regulator (YAP1), TEA domain family member 1 (SV40 transcriptional enhancer factor) (TEAD1), PROX1, and insulin-like growth factor 1 (IGF1) [14]. The gene discussed is GATA4; the disease is cancer.