In patients with RA undergoing anti-TNF therapy, leptin serum levels showed a positive correlation with BMI and VCAM-1; however, no significant correlations were observed between leptin levels and age, disease duration, ESR, CRP, DAS28, lipids, insulin sensitivity, resistin, adiponectin, ghrelin or the cumulative prednisone dose at the time of the study. This evidence concerns the gene GHRL and rheumatoid arthritis.