Similarly, in the rheumatoid-arthritis (RA) joint, activated MCs release pro-inflammatory and immunomodulatory mediators (TNF-A, IL-6, IL-8, VEGF, histamine, heparin, tryptase) that induce angiogenesis, promote cartilage erosions, synoviocyte proliferation, and pain sensitization. This evidence concerns the gene CXCL8 and rheumatoid arthritis.