For example, galectin-3 can bind to the galactose-β1,3N-acetyl-galactosamineα-Thr/Ser, an oncofetal carbohydrate antigen (Thomsen-Friedenreich antigen, TF antigen) that occurs in >90 tumour cells [37,38] and can be proteolytically removed by O-glycanase [39]. This evidence concerns the gene TF and neoplasm.