STAT3 and familial pancreatic carcinoma: Moreover, the polyadenosine diphosphate ribose polymerase inhibitor pamiparib upregulated programmed death ligand 1 (PD-L1) expression on the surface of pancreatic cancer cells in vitro and in vivo via the JAK2/STAT3 pathway, with a significant increase in CD8+ T cells in TME [68].