In pancreatic cancer, the expression of cleaved-caspase3 was elevated in Shikonin-treated PANC-1 and BxPC3 cells, and Shikonin inhibited immune escape from pancreatic cancer by inhibiting the NF-kB/STAT3 pathway and promoting the degradation of PD-L1 [83]. Here, STAT3 is linked to pancreatic neoplasm.