STAT3 and familial pancreatic carcinoma: In addition, some natural inhibitors of STAT3 can enhance the sensitivity of pancreatic cancer cells to the drug, for example, Rhein and Alantolactone enhance tumor sensitivity to erlotinib in a xenograft model and Berbamine induces apoptosis in pancreatic cancer cells in vitro in concert with gefitinib [85,86,87].