In pancreatic cancer cells BxPC-3 and SW1990, miR-1266 significantly increased the nuclear aggregation of STAT3 and NF-κB/p65 and the phosphorylation level of STAT3 and NF-κB/p65 in the nucleus, activated the expression of its downstream genes Bcl2, Bcl-xL, MCL1, and BIRC5, exerted the anti-apoptotic ability of pancreatic cancer cells, and enhanced resistance to gemcitabine [70]. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.