LncRNA FGD5-AS1 in pancreatic cancer can pass through exosomes to TME, where FGD5-AS1 interacts with p300, leading to STAT3 acetylation, which promotes NF-κB nuclear translocation and transcriptional activity and stimulates macrophage polarization toward the M2 type, thereby enhancing pancreatic cancer cell proliferation [57]. This evidence concerns the gene EP300 and familial pancreatic carcinoma.