The Ang II/AT1R axis is responsible for the dopaminergic neuronal loss and reduction of 70% of tyrosine hydroxylase neurons restored with candesartan (Ang II-receptor inhibitor) and azilsartan in rotenone, 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP), and 6-hydroxydopamine (6−OHDA) PD mice models [54]. Here, AGT is linked to Parkinson disease.