Pathologically, the brains of patients with Alzheimer’s dementia are affected by extraneuronal A-β plaques, intraneuronal tangles formed by hyperphosphorylated τ proteins associated with microtubules, neuroinflammation, brain atrophy, especially in the hippocampus and neocortex, and BBB damage [4,61,62]. This evidence concerns the gene TBXT and Alzheimer disease.