H2AX and prostate carcinoma: Another study described that simvastatin (10 to 500 μM) compromises DNA double-strand break repair by triggering the expression of histone 2A family member X (γ-H2AX) and phospho-checkpoint kinase 1 (p-CHK1), suggesting an underlying mechanism for this radiosensitization of prostate cancer cells (PC3 model) [60].