DCX and Alzheimer disease: Moreno-Jimenez et al. quantified the DCX−positive immature neurons in 13 healthy patients at the ages of 43 and 87 years and 45 AD patients between the age of 52 and 97 years of age, and they found that the number of DCX+ cells was markedly reduced in AD patients compared to controls, especially with the advancement of the disease and that maturation of the newly born neurons was defective [43,106].