The risk of MACEs was significantly higher in the high DKK-1 with CAD group than in the low DKK-1 without CAD group (hazard ratio = 10.640, 95% CI: 1.350–83.874, p = 0.025) after adjusting for age, sex, smoking status, hypertension, HOMA-IR index, total cholesterol, HDL cholesterol, triglycerides, eGFR, platelet count, CRP, NT-proBNP, UACR, and the use of statins. This evidence concerns the gene DKK1 and Hypertension.