Insufficient gut CD8α+ Vγ7+ γδ T cell numbers might contribute to the diabetes acceleration, since these cells were decreased in NOD.Vγ4-/- mice (see Figure 9B), but IL-17-biased Vγ6+ gut IELs probably do not, because they did not differ substantially from those of wt NOD mice in any of the γδ T cell-deficient NOD strains. This evidence concerns the gene CD8A and diabetes mellitus.