ASIC3 and rheumatoid arthritis: Although the role of ASIC1a and ASIC3 in cartilage damage during RA is well established, interestingly, we found that overexpression of ASIC2a enhanced the chondroprotective effects of PcTx1 (an ASIC1a-specific inhibitor) and APETx2 (an ASIC3-specific inhibitor) and inhibited the ERK1/2 MAPK signaling pathway [64].