The down-regulation of DSC2 in ESCC results in increased free PG, which can then compete with the β-Catenin in E-Cadherin/β-Catenin complexes, thus causing an increase in β-Catenin and enabling β-Catenin nuclear translocation and induction of transcriptional activity, which subsequently leads to invasion-associated gene expression and ESCC invasion; therefore, it is not hard to understand why the overexpression of DSC2 inhibits the proliferation and metastasis of ESCC. This evidence concerns the gene DSC2 and esophageal squamous cell carcinoma.