This intermediate space allows heterotypic adherens junctions between E-Cadherin on disseminated tumour cells, and N-Cadherin on osteogenic cells, to stimulate mTOR signalling in cancer cells to support growth and metastasis [142,143]; therefore, it is worth exploring their relationship further to help understand the roles in ESCC. Here, CDH1 is linked to esophageal squamous cell carcinoma.