Venous shear (shear rate, 200/s) induces the internalisation of E-Cadherin in metastatic ESCC tumour cells (OC-1 tumour cell line) by activating the Src pathway and phosphorylating tyrosine residues in the short intracytoplasmic tail of E-Cadherin [64]. This evidence concerns the gene CDH1 and esophageal squamous cell carcinoma.