The epidermal growth factor (EGF) in oesophageal cancer cells can activate EGFR [80] to phosphorylate β-Catenin, subsequently resulting in a disrupted bond between β-Catenin and α-Catenin [81,82]; therefore, the connection between E-Cadherin and the actin cytoskeleton is disrupted [83], resulting in a more aggressive phenotype [80]. The gene discussed is EGFR; the disease is carcinoma of esophagus.