Combined with the studies above, we find that GSK3β inhibits the degradation of both β-Catenin and Snail, thus influencing many components such as ZO-1 and activities in the adherens junctions, thus resulting in stronger intercellular junctions, which also indicates the critical role of the related pathways in ESCC. This evidence concerns the gene TJP1 and esophageal squamous cell carcinoma.