Moreover, the abnormal expression and localisation of E-Cadherin enhances the migration and invasion ability of ESCC cells, not only as it leads to the loss of cell polarity and the derangement of normal tissue architecture to reduce adhesion, but also as it maintains tumour basal cells in the basal cell layer of ESCC tissue [54]. The gene discussed is CDH1; the disease is esophageal squamous cell carcinoma.