EPHA3 and esophageal squamous cell carcinoma: The methylation or phosphorylation modifications of adhesion-associated molecules, such as E-Cadherin, EphA3, and β-Catenin, may impact the activation of signalling pathways, which involves the transduction of signalling, transcription regulation, and apoptosis, thus affecting the occurrence and development of ESCC [51,59,80].