One variant was already reported in HS patients: a stop gain mutation NM_172341.4: c.168T>G (p.Tyr56X) of the PSENEN gene previously associated with concomitant HS and Dowling Degos Disease (DDD), a rare genodermatosis, classically characterized by acquired reticular hyperpigmentation in flexural sites [59]. Here, PSENEN is linked to hereditary skin disorder.