A study investigating AYA-CRC patients without indication for LS and FAP revealed heterozygous germline (likely) PVs ((L)PVs) in additional cancer-predisposing genes, including TP53 (MIM *191170), BRCA2 (MIM *600185), PALB2 (MIM *610355), NF1 (MIM *613113), MUTYH (MIM *604933) and MSH3 (MIM *600887) and a homozygous variant in BLM (MIM *604610) in 21% of patients [11], but most of these germline (L)PVs are unlikely to represent a monogenic predisposition to AYA CRC [12]. This evidence concerns the gene TP53 and colorectal carcinoma.