Sodium-glucose co-transporter 2 (SGLT2) is a family of glucose transporter proteins localized in the proximal tubule of the nephron, responsible for the majority of filtered glucose and sodium reabsorption, and SGLT2 inhibitors (SGLT2-Is) are novel drugs for the treatment of T2DM and heart failure [19,20]. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.