KCNK3 and pulmonary arterial hypertension: Studies showed that ONO-RS-082, while non-specific for KCNK3 current, may activate wild-type KCNK3 channel in addition to some mutated channels associated with PAH and that activation of KCNK3 by ONO-RS-082 may occur in the presence of homodimeric (e.g., only WT channel subunits) or heterodimeric (e.g., one WT subunit plus one mutant subunit) channels [11,21].