Diazoxide application in heterologous expression systems can recover KATP channel function containing PAH-associated SUR1 mutations coassembled with Kir6.2 [12] and was more recently shown to attenuate the development of PH in rats exposed to monocrotaline or chronic hypoxia using a protocol of diazoxide exposure of 20 mg/kg/d for 21 days [66]. The gene discussed is ABCC8; the disease is pulmonary arterial hypertension.