Namely, mutations in the KCNK3 channel, and the ABCC8 gene that encodes the SUR1 subunit of the KATP channel, may underlie genetically predisposed PAH, and KCNK3 and/or KATP channel dysfunction may contribute to the development of PH in general. The gene discussed is ABCC8; the disease is pulmonary arterial hypertension.