In vitro and in vivo experiments showed that overexpression of the tumor suppressor circ-RHOBTB3 could significantly inhibit the invasion and metastasis of colorectal cancer cells by binding to the HuR (ELAVL1) protein and downregulating its expression, thereby reducing the expression of the downstream target gene PTBP1 [136]. The gene discussed is ELAVL1; the disease is neoplasm.