Transforming growth factor beta 1 (TGF-β1), tumor necrosis factor alpha (TNF-α), and hypoxia cooperate in the triggering of EMT both in cancer and fibrosis [25,26], converging in the induction of Snail activity through different mechanisms including the activation of transcription factor NF-kB [26]. The gene discussed is TGFB1; the disease is cancer.