We measured in sera comparably unknown proinflammatory factors—namely chemokines (CCL2, CCL4, CCL11) and PGE2—in children with controlled and refractory epilepsy, aiming to explore the correlation between the interictal cytokine quantitative levels with the seizure frequency and severity and the duration of epilepsy from bench to bedside. Here, CCL2 is linked to epilepsy.