CCL11 and Cognitive impairment: Furthermore, Parajuli et al. showed that CCL11 concentrations in serum and liquor samples showed an upward trend related to age; it is hypothesised that CCL11 may have a suppressing influence on the neurogenesis of the CNS, prompting cognitive impairment via enhanced gliosis, hyperresponsiveness to inflammatory molecules and ROS injury [50,51,52].