In contrast, the presence of anti-SOD1 antibodies has shown a positive association with survival in sALS patients [45]; however, it should be noted that although T helper lymphocytes and cytotoxic T lymphocytes infiltrate the areas affected by degeneration, no infiltration by B lymphocytes has been found in the tissues of ALS patients [46], although the expression of the IgG subclass in ALS has been found to be altered [47], which suggests some dysfunction in the B lymphocytes. Here, SOD1 is linked to amyotrophic lateral sclerosis.