SOD1 and amyotrophic lateral sclerosis: In SOD1G93A and TDP43A315T mice, early treatment with anti-NK cell antibodies has been shown to increase survival and delay the onset of the disease [36]; however, NK cell depletion has been shown to prolong survival in female, but not male, SOD1 mice, thus suggesting that NK cells are related to ALS in a sex-specific manner [37].