CD4 and amyotrophic lateral sclerosis: At present, the early pathogenetic role of such cells cannot be hypothesized, even if it has been shown in an animal model of SOD1-ALS T-lymphocytes, that such cells infiltrate the CNS before the onset of symptoms [63]; however, the balance between CD4+ and CD8+, and between Treg and Teffs cells, has been reported to influence the prognosis of the disease (see Figure 3).