C9orf72 and amyotrophic lateral sclerosis: Moreover, mice with full C9orf72 ablations show a typical induction of ALS pathological hallmarks, including motor neuron degeneration, gliosis, and increased ubiquitination, which is associated with a massive infiltration (detected by postmortem histopathological analyses) of histiocytes/macrophages and lymphocytes (particularly B220/CD45R-positive B-lymphocytes) in the CNS, as well as in the spleen, bone marrow, liver, kidneys, and lungs [14].