Synaptic plasticity regulation genes, especially the ones that encode neurotrophic factor and their receptors, are thus believed to be involved in neuronal development, synapse generation, and response to stress/anxiety stimuli [12,13] and may have important roles in the molecular mechanism of cognition impairment in schizophrenia, MDD and some other psychiatric disorders, including nerve growth factor receptor (NGFR). The gene discussed is NGFR; the disease is major depressive disorder.