CHRNA7 and Mental deterioration: The stimulation of α7 nicotinic acetylcholine receptor (α7-nAChR) has been found to attenuate cognitive decline, neuroinflammation, and oxidative stress [90], and reduced expression of α7-nAChR is detected in microglia and astrocytes after chronic sleep deprivation, accompanied by increased levels of proinflammatory factors and reduced levels of anti-inflammatory factors and antioxidant enzymes, which can be reversed by the α7-nAChR agonist PHA-543613 through the PI3/AKT/GSK-3β pathway [91].