As PGE2 is responsible for radioresistance [69] and temozolomide (TMZ) resistance [70], the enzymes involved in the synthesis of arachidonic acid C20:4n-6—in particular, Elovl5 and Fads2/D6D—are also responsible for the resistance to GBM anti-tumor therapy [69]. Here, FADS2 is linked to neoplasm.