Therefore, other FC assessments would be used to estimate the functional abnormality and its relationship with tau burden, and additional regional connectome influenced by cognition impairment-related pathological alterations would be analyzed in further studies, which might offer new insights into the pathological interpretation of the relationship between tau accumulation and the functional connectivity and find more potential biomarkers in the AD continuum. The gene discussed is MAPT; the disease is Cognitive impairment.