GRIN2A and major depressive disorder: Mice lacking the GluN2A subunit do not exhibit depression-like behavior after LPS treatment, which indicates an important regulatory role of the GluN2A subunit in neuroinflammation-related depression [116] In line with the complex regulatory mechanisms of NMDARs in anxiety studies, antidepressant studies involving NMDARs also have shown contradictory conclusions from different subunits in different brain regions.