However, there is substantial evidence from rodent models relevant to anxiety that the direct NMDAR agonists glycine and d-serine have prominent anxiogenic-like effects in mice in multiple tests of anxiety and that glycine transporter-1 (GlyT-1) inhibitors such as ALX-5407 could also cause anxiety in mice [83], while in mutant mice with reduced NMDA-NR1 glycine affinity, they demonstrated an anxiolytic-like phenotype [83]. Here, GRIN1 is linked to Anxiety.