GBA carriers suffer from severe autonomic dysfunction (orthostatic hypotension; urinary, sexual, and bowel dysfunction, and sweating), sleep disorders, neuropsychiatric disturbances (anxiety, depression, apathy, visual hallucinations, and other psychotic symptoms), and cognitive decline [190,294,295,296,301,302,303,304,305,306]. Here, GBA1 is linked to major depressive disorder.