GBA1 and Mental deterioration: In a recent multicenter study investigating clinical and genetic data of 366 subjects (58 GBA+DBS+ vs. 82 GBA+DBS− vs. 98 GBA−DBS+ vs. 128 GBA−DBS− subjects), stratified according to GBA mutation severity and longitudinally followed up to 60 months after surgery, showed a faster cognitive decline in GBA-carriers undergoing DBS compared to all other groups, suggesting a combined detrimental effect of GBA mutations and DBS on cognition [314].