PRKN and Parkinson disease: However, only some of these genes (e.g., SNCA, LRRK2, VPS35, PRKN, PINK1, GBA, and DJ-1) have been convincingly demonstrated as being related to PD pathogenesis, while the role of other genes is still debated and validation is still required (e.g., LRP10 [10,11], TMEM230 [12,13,14], DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 [15]).