To explore the effect of PBM on long-term plasticity, Shen et al. (2021) [58] showed that photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer’s disease, which has critical roles in LTP and LTD [59,60]. This evidence concerns the gene MAPK10 and early-onset autosomal dominant Alzheimer disease.