TMC1 and Hodgkins lymphoma: hiPSC lines and corrected isogenic controls have also been generated from patients with mutations in other genes that affect HC development, such as the Transmembrane Channel-like protein isoform-1 (TMC1) gene that encodes for a key protein of the mechanotransduction channel [90,95]; Wang et al. (2020) have generated an hiPSC line carrying a TMC1 c.1253 T > A mutation that constitutes the human counterpart to the Beethoven mouse model [96]; gene editing of the Tmc1 mutation has been shown to significantly ameliorate the progressive HL seen in these mice [34,97,98].