This is the most prevalent mutation in MT-RNR1, and it results in increased binding of aminoglycoside antibiotics (AGs) to the mitochondrial ribosome and AG-induced HL; it is therefore important to identify MT-RNR1 variants that may render individuals more likely to develop AG-induced HL prior to the administration of this type of anti-infective [121]. This evidence concerns the gene MCAT and Hodgkins lymphoma.