Relative to synovial tissue samples from OA patients, those from RA patients contained increased percentages of CD183+T-bet+ Th1 (Figure 2A) and CD185+BATF+ Tfh (Figure 3B) cells, whereas the frequency of CD25+Foxp3+ Tregs (Figure 2C) was reduced. This evidence concerns the gene CXCR3 and rheumatoid arthritis.