Given that the inflammation–coagulation axis is also an important component of COVID-19-associated ALI/ARDS, the signaling pathways engaged by TNFα and thrombin to activate NF-κB may also be operative in ECs infected with SARS-CoV-2 [42,53,54,55,56,57,58]. This evidence concerns the gene NFKB1 and acute respiratory distress syndrome.