It is worth noting that the key regulators of ferroptosis such as GPX4 [80,107], ACSL4 [109], SLC7A11 [114,118], p62–Keap1–Nrf2 signaling pathway [25,110], and p53 signaling pathway [122], etc., are of great significance for regulating ferroptosis-related liver diseases. The gene discussed is ACSL4; the disease is liver disorder.