KEAP1 and hepatocellular carcinoma: Moreover, Sun et al. [25] reported that the p62–Keap1–Nrf2 pathway plays a pivotal role in protecting HCC cells from ferroptosis induced by ferroptosis-inducing compounds (such as Sorafenib, Erastin, and buthionine sulfoximine) via increasing the expression of several Nrf2-targeting genes (NQO1, HO1, FTH1) associated with ROS and iron metabolism.