ABCB11 and cholestasis: Instead, the main reason for the non-occurrence of cholestasis with Pi and Te in vivo seems to be kinetic in nature, and related to the cellular levels of the azole compounds achieved in the different types of experiments: as shown in Table 1, the IC50 for BSEP inhibition is ~5–50 fold above the intra-hepatic concentration measured at the top dose in previous animal studies [8].