c-Src, PI3K and Akt inhibitors, as well as their respective siRNAs, inhibited apelin-facilitated promotion of miR-106a-5p synthesis, suggesting that apelin inhibits TIMP2 synthesis and facilitates prostate cancer migration by increasing miR-106a-5p production through the c-Src/PI3K/Akt pathway. This evidence concerns the gene APLN and Familial prostate cancer.