The overexpression of SLFN12 in human HIEC-6 and/or FHs 74 Int cells led to a similar augmentation in the expression of the following differentiation and restitution genes: HES2, CARD9, and SLC19A2 and the following obesity-related genes: FBXW7, STXBP4, SPARCL1, and UTS in comparison with the increased expression observed in the RNA Seq data. Here, SLFN12 is linked to obesity due to melanocortin 4 receptor deficiency.