Additionally, increased TRPC1 and TRPC5 expression in failing human hearts [93,105,106], increased TRPC6 mRNA in human LV with dilated cardiomyopathy [100], and decreased expression of TRPC4 in isolated LV myocytes from patients with ischemic cardiomyopathy and severe HF have been shown [105,107] (Table 1). The gene discussed is TRPC5; the disease is hydrops fetalis.