TRPC4 and hydrops fetalis: Additionally, increased TRPC1 and TRPC5 expression in failing human hearts [93,105,106], increased TRPC6 mRNA in human LV with dilated cardiomyopathy [100], and decreased expression of TRPC4 in isolated LV myocytes from patients with ischemic cardiomyopathy and severe HF have been shown [105,107] (Table 1).