Indeed, in different in vivo experimental rodent models of hypertrophy and HF induced by pressure or volume overload (abdominal, ascending or transverse aortic constriction, Dahl salt-sensitive, spontaneously hypertensive (SHR), myocardial infraction, ischemia-reperfusion injury) or by neurohormonal stress (PE, Endothelin-1 (ET-1), AngII, Isoproterenol), an increased expression of TRPC1 [54,57,59,65,82,88,89,90,91,92], TRPC2 [90], TRPC3 [59,90,93,94,95,96], TRPC4 [59,81,97], TRPC5 [83] and TRPC6 [59,72,81,90,94,95,96,98,99,100,101,102,103,104] has been reported. Here, AGT is linked to hydrops fetalis.