MAPK1 and cancer: The GO enrichment analyses demonstrated that eGenes regulated by risk-eSNPs were mainly enriched in cell fate commitment, cellular response to retinoic acid, ERK1 and ERK2 cascade, neuron differentiation, and Wnt signaling pathways; they were also enriched in carcinoma, cancers, the pluripotency of stem cells, and mTOR signaling pathways in KEGG analyses (Figure 3).