Collectively, these findings, combined with the observation that pharmacological inhibition of caspase-10 attenuated cells death by ~50%, provided strong evidence that mCD40L-mediated apoptosis involves partial crosstalk with intracellular TRAIL-mediated activation of the mitochondrial apoptotic pathway, which amplifies and accelerates CD40-mediated death in CRC cells. Here, CD40 is linked to colorectal carcinoma.