Thus, our findings have further unravelled the multifaceted pro-apoptotic properties and unique nature of the CD40/mCD40L dyad, whilst also providing novel evidence of the direct TNFR crosstalk that drives rapid carcinoma cell death, which has implications for the use of CD40 as an increasingly attractive therapeutic target in cancer [50]. The gene discussed is TNFRSF1A; the disease is cancer.